External otitis is a diffuse inflammation around the external auditory canal and\nauricle, which is often occurred by microbial infection. This disease is generally treated\nusing antibiotics, but the frequent occurrence of antibiotic resistance requires the\ndevelopment of new antibiotic agents. In this context, unexplored bioactive natural\ncandidates could be a chance for the production of targeted drugs provided with\nantimicrobial activity. In this paper, microbial pathogens were isolated from patients with\nexternal otitis using ear swabs for over one year, and the antimicrobial activity of the\ntwo methanol extracts from selected marine (Dunaliella salina) and freshwater\n(Pseudokirchneriella subcapitata) microalgae was tested on the isolated pathogens. Totally,\n114 bacterial and 11 fungal strains were isolated, of which Staphylococcus spp. (28.8%) and\nPseudomonas aeruginosa (P. aeruginosa) (24.8%) were the major pathogens. Only three\nStaphylococcus aureus (S. aureus) strains and 11 coagulase-negative Staphylococci showed\nresistance to methicillin. The two algal extracts showed interesting antimicrobial properties,\nwhich mostly inhibited the growth of isolated S. aureus, P. aeruginosa, Escherichia coli,\nand Klebsiella spp. with MICs range of 1.4 Ã?â?? 109 to 2.2 Ã?â?? 1010 cells/mL. These results suggest\nthat the two algae have potential as resources for the development of antimicrobial agents.
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